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NEWOpen + Clinical
ASMD / Xenpozyme QSP v2.0
Adult and paediatric olipudase alfa ERT model for acid sphingomyelinase deficiency.
Rare disease · Lysosomal storage
SBML v2.0 adult/paediatric available
QSP–SBML intelligence · Living model catalogue
IQANOVA ATLAS
Continuously updated mechanistic model intelligence: from open SBML blueprints to validated, subscription-grade QSP decision engines for drug discovery, clinical strategy and regulatory documentation.
8active model pages
SBMLopen structural models
CSV/JSONreports, tables and APIs
ATLAS product system
From publication to decision engine
Literature extraction → SBML reconstruction → calibration → V&V → virtual populations → reports, dashboards and partner-specific model releases.
NewASMD / Xenpozyme v2.0
Rare diseasePompe QSP v2.0
ImmunologyAsthma CYTOCON–EHMN
CNSAnaesthetic combo PK/PD
What ATLAS contains
Each model page separates public educational assets from subscription-grade layers: fitted parameters, calibration notebooks, virtual patients, uncertainty/sensitivity outputs, validation reports and quarterly update logs.
SBML-encoded structure
Compartments, species, reactions, rate rules, dose events and simulation-ready files.
Parameter governance
Traceable values, assumptions, prior ranges, calibration targets and version history.
Clinical endpoint mapping
Biomarkers and clinical readouts mapped to mechanistic states and observable equations.
Regulatory artefacts
Context-of-use, V&V checks, report packs, decision tables and audit-ready evidence maps.
Model catalogue
ASMD has been added as a new rare-disease model family with adult and paediatric SBML v2.0 files, CSV/JSON reports, figures and the full pipeline bundle.
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OPENOpen + Clinical
Pompe QSP v2.0
ERT optimisation across LOPD, IOPD CRIM+ and IOPD CRIM− populations.
Rare disease · Glycogen storage
SBML and bundle available
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MODELOpen + Subscription
CAR‑T QSP resistance model
Mechanistic immune-oncology model covering exhaustion, PD‑1/PD‑L1 and antigen escape.
Immuno-oncology
Publication-linked model page
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MODELOpen + Subscription
GLP‑1 / Semaglutide Ageing QSP
Weight, HbA1c, nausea and ageing-state model for GLP‑1 therapies.
Metabolic
Repository links pending
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MODELSubscription
EPO / ESA Erythropoiesis Digital Twin
ESA response model with erythropoiesis, miR‑486, mTOR, HIF‑PHI and SUMO recycling hooks.
Haematology
SBML pending
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DRAFTOpen scaffold planned
Aspirin COX‑1 / TXB₂ / Resolvin QSP
ASA PK to irreversible COX‑1 acetylation, TXB₂ turnover and aspirin-triggered resolvin branch.
Cardiovascular · Inflammation
SBML pending
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POSTEROpen + Subscription
Asthma CYTOCON–EHMN2026 Neural‑ODE QSP
Genome-scale immunometabolic asthma model integrating CYTOCON DB, EHMN2026 and neural ODE surrogates.
Respiratory · Immunology
Poster/manuscript draft
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DRAFTSubscription research
Integrated Anaesthetic PK/PD Combo Model
Propofol, sevoflurane and xenon model linking PK, receptor mechanisms, BIS, MAP, ventilation and recovery risks.
Anaesthesia · CNS
SBML pending
New timestamped version
GLP‑1 Ageing QSP v4.2 added without replacing the base model
Release glp1_v4_2_20260524_1030Z was added at 2026-05-24T10:30:21Z. The original GLP‑1 model page remains available, while this v4.2 bundle is stored as a separate versioned SBML/CSV/PDF release.
Free vs subscription boundary
ATLAS Open provides structural SBML, static release files and publication-linked model cards. Subscription tiers add quarterly curation, calibration refreshes, VPOP scenarios, partner-specific COU, regulatory-ready dossiers and decision dashboards.