GLP‑1 / Semaglutide Ageing QSP v4.2
A new timestamped ATLAS version was added from the uploaded GLP‑1 bundle. The earlier GLP‑1 model page remains available and unchanged as the base model record.
What this version adds
This page is a versioned ATLAS record for the uploaded IQANOVA_GLP1_ATLAS_Bundle. It is added as a separate release rather than replacing the prior GLP‑1 / Semaglutide Ageing QSP page.
- 13 species / state variables listed in S01_species_table.csv
- 25 parameters listed in S02_parameter_table.csv
- 11 PASS checks in S07_qc_matrix.csv
- 5 combination scenarios in combination_optimisation.csv
- Preprint, supplementary documents, SBML, QC script, CSV tables and source bundle are archived under a timestamped folder.
Version provenance
| ATLAS build | v2026.05.24-1030Z |
| Build timestamp | 2026-05-24T10:30:21Z |
| Release ID | glp1_v4_2_20260524_1030Z |
| Source bundle | IQANOVA_GLP1_ATLAS_Bundle(1).zip |
| Preservation policy | Existing GLP‑1 page retained; this is an additive versioned release. |
Pipeline execution snapshot
Summary extracted from the uploaded GLP‑1 ATLAS bundle. The detailed source-page HTML is archived in the release reports folder for audit.
| Stage | Name | Status | Output / notes |
|---|---|---|---|
| 0.0 | LDI Agent / literature-data intake | COMPLETE | 13 databases queried; contradiction rows retained in the source page. |
| 0A–0K | Intake → SBML → QC → Export | COMPLETE | 31 PASS · 3 WARN · 0 FAIL · libSBML 0 errors in source bundle report. |
| 2 | SBML extension v4.2 | COMPLETE | QC-UNIT-001 fix, recalibration, FRA clamp and MIRIAM annotation check. |
| 5 | Calibration | COMPLETE | RMSE W and HbA1c values reported in source page; calibration table included. |
| 7 | GSA | COMPLETE | LHS N=3,000 ±30%; H1–H4 hypothesis outputs included. |
| 9 | Bayesian meta-analysis | COMPLETE | CSV table and S4 PDF included. |
| 10 | Combination optimisation | COMPLETE | Five scenario rows included; ageing add-on comparisons retained. |
Downloads and artefacts
All files are stored under versioned folders so future GLP‑1 releases can be added without overwriting this one.
CSV / data tables
The model package includes machine-readable output tables for species, parameters, calibration, simulation, combinations, GSA, Bayesian meta-analysis and QC.
| Table | Rows | Columns | Open |
|---|---|---|---|
| S01_species_table.csv | 13 | 6 | Open CSV |
| S02_parameter_table.csv | 25 | 6 | Open CSV |
| S03_calibration_fit.csv | 8 | 6 | Open CSV |
| S04_simulation_trajectories.csv | 105 | 14 | Open CSV |
| S05_combination_results.csv | 5 | 10 | Open CSV |
| S06_GSA_hypotheses.csv | 7 | 6 | Open CSV |
| S07_qc_matrix.csv | 13 | 4 | Open CSV |
| Bayesian_meta_analysis.csv | 9 | 7 | Open CSV |
| combination_optimisation.csv | 5 | 7 | Open CSV |
| GSA_hypothesis_summary.csv | 8 | 5 | Open CSV |
Use in ATLAS
This version can be used as a locked reference release for comparison against later quarterly updates. Future GLP‑1 releases should be added as additional timestamped pages and folders rather than replacing this record.