[
  {
    "id": "asmd-xenpozyme",
    "title": "ASMD / Xenpozyme QSP v2.0",
    "short": "Adult and paediatric olipudase alfa ERT model for acid sphingomyelinase deficiency.",
    "area": "Rare disease \u00b7 Lysosomal storage",
    "tag": "NEW",
    "tier": "Open + Clinical",
    "status": "SBML v2.0 adult/paediatric available",
    "page": "models/asmd-xenpozyme.html",
    "features": [
      "Residual ASM activity and sphingomyelin burden",
      "Olipudase alfa PK, tissue uptake and lysosomal delivery",
      "Lyso\u2011SM, ceramide, spleen, liver, DLCO and platelet endpoints",
      "Adult-to-paediatric dose-bridging and regimen optimisation"
    ],
    "free": [
      "SBML v2.0 adult and paediatric files",
      "v0.2/v0.3 development SBML scaffold",
      "Selected CSV/JSON reports",
      "Figures and static artefact bundle"
    ],
    "paid": [
      "Quarterly re-calibration against new ASCEND/OLE evidence",
      "Patient-level virtual twin extensions",
      "Regulatory V&V40 dossier and COU refinement",
      "Partner-specific dose and benefit-risk scenarios"
    ],
    "downloads": [
      [
        "Adult SBML v2.0",
        "../sbml/ASMD_Xenpozyme_QSP_v2_0_adult.xml"
      ],
      [
        "Paediatric SBML v2.0",
        "../sbml/ASMD_Xenpozyme_QSP_v2_0_paediatric.xml"
      ],
      [
        "Full ASMD v2 bundle",
        "../downloads/asmd_v2_full_bundle.zip"
      ],
      [
        "Decision table CSV",
        "../data/asmd/ASMD_Xenpozyme_QSP_v2_0_decision_table.csv"
      ],
      [
        "Model summary JSON",
        "../data/asmd/ASMD_Xenpozyme_QSP_v2_0_model_summary.json"
      ]
    ]
  },
  {
    "id": "pompe-v2",
    "title": "Pompe QSP v2.0",
    "short": "ERT optimisation across LOPD, IOPD CRIM+ and IOPD CRIM\u2212 populations.",
    "area": "Rare disease \u00b7 Glycogen storage",
    "tag": "OPEN",
    "tier": "Open + Clinical",
    "status": "SBML and bundle available",
    "page": "models/pompe-v2.html",
    "features": [
      "Avalglucosidase and cipaglucosidase + miglustat regimens",
      "CRIM-status stratification and ITI benefit",
      "Hex4, 6MWT and FVC endpoint mapping",
      "ASME V&V40-style dossier"
    ],
    "free": [
      "Model page and publication description",
      "Selected SBML / bundle artefacts",
      "Decision table CSV"
    ],
    "paid": [
      "Clinical layer",
      "Quarterly update and partner scenarios"
    ]
  },
  {
    "id": "car-t",
    "title": "CAR\u2011T QSP resistance model",
    "short": "Mechanistic immune-oncology model covering exhaustion, PD\u20111/PD\u2011L1 and antigen escape.",
    "area": "Immuno-oncology",
    "tag": "MODEL",
    "tier": "Open + Subscription",
    "status": "Publication-linked model page",
    "page": "models/car-t.html",
    "features": [
      "T-cell expansion and tumour killing",
      "Exhaustion and checkpoint feedback",
      "Antigen escape and combination hypotheses"
    ],
    "free": [
      "Model card and publication link"
    ],
    "paid": [
      "Calibrated virtual populations",
      "Combination simulations"
    ]
  },
  {
    "id": "glp1-ageing",
    "title": "GLP\u20111 / Semaglutide Ageing QSP",
    "short": "Weight, HbA1c, nausea and ageing-state model for GLP\u20111 therapies.",
    "area": "Metabolic",
    "tag": "MODEL",
    "tier": "Open + Subscription",
    "status": "Repository links pending",
    "page": "models/glp1-ageing.html",
    "features": [
      "PK/PD and metabolic endpoints",
      "Ageing-state modifiers",
      "Nausea tolerability module"
    ],
    "free": [
      "Model description and manuscript link"
    ],
    "paid": [
      "Parameterised model and GSA outputs"
    ]
  },
  {
    "id": "epo-erythropoiesis",
    "title": "EPO / ESA Erythropoiesis Digital Twin",
    "short": "ESA response model with erythropoiesis, miR\u2011486, mTOR, HIF\u2011PHI and SUMO recycling hooks.",
    "area": "Haematology",
    "tag": "MODEL",
    "tier": "Subscription",
    "status": "SBML pending",
    "page": "models/epo-erythropoiesis.html",
    "features": [
      "Hb response dynamics",
      "ESA optimisation",
      "HIF\u2011PHI perturbation scenarios"
    ],
    "free": [
      "Model description"
    ],
    "paid": [
      "Digital twin layer"
    ]
  },
  {
    "id": "aspirin-cox1",
    "title": "Aspirin COX\u20111 / TXB\u2082 / Resolvin QSP",
    "short": "ASA PK to irreversible COX\u20111 acetylation, TXB\u2082 turnover and aspirin-triggered resolvin branch.",
    "area": "Cardiovascular \u00b7 Inflammation",
    "tag": "DRAFT",
    "tier": "Open scaffold planned",
    "status": "SBML pending",
    "page": "models/aspirin-cox1.html",
    "features": [
      "ASA PK and salicylate handling",
      "Irreversible COX\u20111 acetylation and platelet turnover",
      "TXB\u2082 inhibition and AT\u2011RvD1 extension"
    ],
    "free": [
      "Draft model card and diagrams"
    ],
    "paid": [
      "Formulation PK/PD and DDI simulations"
    ]
  },
  {
    "id": "asthma-cytocon",
    "title": "Asthma CYTOCON\u2013EHMN2026 Neural\u2011ODE QSP",
    "short": "Genome-scale immunometabolic asthma model integrating CYTOCON DB, EHMN2026 and neural ODE surrogates.",
    "area": "Respiratory \u00b7 Immunology",
    "tag": "POSTER",
    "tier": "Open + Subscription",
    "status": "Poster/manuscript draft",
    "page": "models/asthma-cytocon.html",
    "features": [
      "CYTOCON immune-cell/cytokine priors",
      "EHMN2026 metabolic bridge metabolites",
      "Neural ODE surrogate for virtual populations"
    ],
    "free": [
      "Poster-style summary"
    ],
    "paid": [
      "Population-scale calibrated simulation"
    ]
  },
  {
    "id": "anaesthetics-pkpd",
    "title": "Integrated Anaesthetic PK/PD Combo Model",
    "short": "Propofol, sevoflurane and xenon model linking PK, receptor mechanisms, BIS, MAP, ventilation and recovery risks.",
    "area": "Anaesthesia \u00b7 CNS",
    "tag": "DRAFT",
    "tier": "Subscription research",
    "status": "SBML pending",
    "page": "models/anaesthetics-pkpd.html",
    "features": [
      "Propofol TCI and gas-agent PBPK",
      "GABA, K2P, HCN and NMDA modules",
      "BIS, MAP, VentDrive, nausea and delirium proxies"
    ],
    "free": [
      "Model card and mechanism diagram"
    ],
    "paid": [
      "Controller simulations and safety scenarios"
    ]
  },
  {
    "id": "glp1-ageing-v4-2-20260524-1030Z",
    "title": "GLP\u20111 / Semaglutide Ageing QSP v4.2 (20260524-1030Z)",
    "short": "Timestamped v4.2 recalibrated GLP\u20111 ageing model release added from uploaded ATLAS bundle; base GLP\u20111 page preserved.",
    "area": "Metabolic \u00b7 Ageing \u00b7 Obesity",
    "tag": "VERSIONED",
    "tier": "Open + Subscription",
    "status": "Timestamped v4.2 release added 2026-05-24T10:30:21Z",
    "page": "models/glp1-ageing-v4-2-20260524-1030Z.html",
    "parent_model": "glp1-ageing",
    "release_id": "glp1_v4_2_20260524_1030Z",
    "build_timestamp_utc": "2026-05-24T10:30:21Z",
    "features": [
      "SBML v4.2 recalibrated release archived with SHA-256 manifest",
      "CSV outputs for species, parameters, calibration, trajectories, GSA, Bayesian meta-analysis and QC",
      "Preprint, supplementary documents and source bundle retained as timestamped artefacts",
      "Designed for future quarterly comparison without overwriting older releases"
    ],
    "free": [
      "Timestamped model page",
      "SBML XML v4.2",
      "CSV data tables",
      "Release manifest and source bundle archive"
    ],
    "paid": [
      "Quarterly GLP-1 evidence refreshes",
      "Partner-specific calibration and virtual population scenarios",
      "Regulatory-ready V&V documentation and COU refinement",
      "Combination optimisation and dashboard deployment"
    ],
    "downloads": [
      [
        "SBML v4.2",
        "../sbml/glp1/versions/glp1_v4_2_20260524_1030Z/IQANOVA_GLP1_Ageing_QSP_v4_2_recalibrated_20260524-1030Z.xml"
      ],
      [
        "Release manifest",
        "../data/glp1/versions/glp1_v4_2_20260524_1030Z/glp1_v4_2_20260524_1030Z_manifest.json"
      ],
      [
        "Source bundle",
        "../downloads/glp1/versions/glp1_v4_2_20260524_1030Z/IQANOVA_GLP1_ATLAS_Bundle_original_20260524-1030Z.zip"
      ]
    ]
  }
]